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Sep 8, Margaret A Stanley,1 David M Winder,1 Jane C Sterling,1 and Peter KC Goon Keywords: Anal cancer, Anal intraepithelial neoplasia, AIN, . Another important study has reported on a cohort of 72 patients with AIN, followed.
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues
Our goal was to summarize the literature on anal cancer, HSIL and HPV .. age of 42 years compared with 72 years for women with anal cancer in the general.
Description:Abstract Objective The incidence of anal cancer is higher in women than men in the general population and has been increasing for several decades. Similar to cervical cancer, most anal cancers are associated with human papillomavirus HPV and it is believed that anal cancers are preceded by anal high-grade squamous intraepithelial lesions HSIL. Our goal was to summarize the literature on anal cancer, HSIL and HPV infection in women, and provide screening recommendations in women. Results Anal HPV infection is common in women but is relatively transient in most. The risk of anal HSIL and cancer varies considerably by risk group, with HIV-infected women and those with a history of lower genital tract neoplasia LGTN at highest risk compared with the general population. Conclusions While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and have digital anorectal examinations to detect anal cancers.